Allelic changes at multiple regions of chromosome 5 are associated with progression of urinary bladder cancer
作者: Rolf von KnoblochPeter BugertAnna JauchTilman KälbleGyula Kovacs
作者单位: 1Laboratory of Molecular Oncology, Department of Urology, Ruprecht‐Karls University, Heidelberg, Germany
2 Department of Urology, Philipps University, Marburg, Germany
3 Institute of Human Genetics, Ruprecht‐Karls University, Heidelberg, Germany
4 Laboratory of Molecular Oncology, Department of Urology, Ruprecht‐Karls University of Heidelberg, Im Neuenheimer Feld 365, Rm 002, D‐69120 Heidelberg, Germany.
刊名: The Journal of Pathology, 2000, Vol.190 (2), pp.163-168
来源数据库: Wiley Journal
DOI: 10.1002/(SICI)1096-9896(200002)190:2<163::AID-PATH509>3.0.CO;2-0
关键词: chromosome 5microsatellitestumour progressionbladder cancer
原始语种摘要: Abstract(#br)This study has analysed 65 urothelial carcinomas for allelic imbalance at 22 loci of chromosome 5 and has determined three regions of interest. A commonly duplicated region was mapped to chromosome 5p between loci D5S1473 and D5S819, one region of deletion to chromosome 5q22–23 between loci D5S2055 and D5S659, and another to chromosome 5q33–34 between loci D5S1456 and D5S1465. An allelic imbalance was detected in 54% of the cases. Only 10% of grade 1 tumours showed allelic changes at chromosome 5, whereas 60% and 63% of grade 2 and grade 3 cancers, respectively, had alterations of chromosome 5. The frequency of chromosome 5 changes increased from 24% in pTa tumours up to 72% in pT3–4 tumours. Of particular interest, ten out of 12 urothelial carcinomas showing metastatic...
全文获取路径: Wiley  (合作)

  • bladder 膀胱
  • chromosome 染色体
  • urinary 尿的
  • cystectomy 膀胱切除术
  • grade 品位
  • allelic 等位的
  • grading 粒级成层
  • imbalance 不稳定
  • tumour 肿瘤
  • region 地域