|作者：||Rolf von Knobloch, Peter Bugert, Anna Jauch, Tilman Kälble, Gyula Kovacs|
1Laboratory of Molecular Oncology, Department of Urology, Ruprecht‐Karls University, Heidelberg, Germany
2 Department of Urology, Philipps University, Marburg, Germany
3 Institute of Human Genetics, Ruprecht‐Karls University, Heidelberg, Germany
4 Laboratory of Molecular Oncology, Department of Urology, Ruprecht‐Karls University of Heidelberg, Im Neuenheimer Feld 365, Rm 002, D‐69120 Heidelberg, Germany.
|刊名：||The Journal of Pathology, 2000, Vol.190 (2), pp.163-168|
|关键词：||chromosome 5; microsatellites; tumour progression; bladder cancer;|
|原始语种摘要：||Abstract(#br)This study has analysed 65 urothelial carcinomas for allelic imbalance at 22 loci of chromosome 5 and has determined three regions of interest. A commonly duplicated region was mapped to chromosome 5p between loci D5S1473 and D5S819, one region of deletion to chromosome 5q22–23 between loci D5S2055 and D5S659, and another to chromosome 5q33–34 between loci D5S1456 and D5S1465. An allelic imbalance was detected in 54% of the cases. Only 10% of grade 1 tumours showed allelic changes at chromosome 5, whereas 60% and 63% of grade 2 and grade 3 cancers, respectively, had alterations of chromosome 5. The frequency of chromosome 5 changes increased from 24% in pTa tumours up to 72% in pT3–4 tumours. Of particular interest, ten out of 12 urothelial carcinomas showing metastatic... growth in regional lymph nodes at the time of cystectomy had alterations at chromosome 5. No specific region, but genetic changes in general were associated with the grading and staging of bladder cancers. Copyright © 2000 John Wiley & Sons, Ltd.|