Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction
作者: Tomi StrengKarl‐Erik AnderssonPetter HedlundChristian GratzkeEnrico BaroniDaniele D'AmbrosioFabio Benigni
作者单位: 1Department of Pharmacology, Turku University, Turku, Finland
2 Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
3 Urological Research Institute, San Raffaele University, Milan, Italy
4 Department of Clinical Pharmacology, Linköping University, Linköping, Sweden
5 Department of Urology, Munich University Hospital, Germany
6 BioXell, Milano, Italy
刊名: BJU International, 2012, Vol.110 (2b), pp.E125-E131
来源数据库: Wiley Journal
DOI: 10.1111/j.1464-410X.2011.10838.x
关键词: BXL628vitamin D analoguepartial urethral obstructionantimuscarinics
原始语种摘要: What's known on the subject? and What does the study add?(#br)It has previously been shown that elocalcitol might protect bladder contractile function in experimental models and that elocalcitol has beneficial effects in patients with LUTS. In humans, elocalcitol was demonstrated with a very good safety profile but only exhibited limited efficacy on LUTS in patients with BPH and overactive bladder (OAB). Recent reports show that therapies with antimuscarinics, when combined with other drugs in clinical use, might perform better than a monotherapy in managing LUTS. It is not known how a combination of elocalcitol and an antimuscarinic performs on bladder dysfunction.(#br)The present study suggests that concomitant use of secosteroids and antimuscarinics has additive beneficial effects on...
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关键词翻译
关键词翻译
  • bladder 膀胱
  • obstruction 塞住
  • treated 加工的
  • combining 组合
  • urethral 尿道的
  • micturition 撒尿
  • combined 组合
  • analogue 相似体
  • vehicle 
  • urinary 尿的