Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling
作者: Hong GeYamei ZhaoXinyan ShiZhen TanXiaorui ChiMan HeGuohui JiangLixia JiHongmei Li
作者单位: 1Department of Oncology The Affiliated Hospital of Qingdao University Qingdao China
2 Department of Oncology Weifang Hanting District People's Hospital Weifang China
3 Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao University Qingdao China
4 Department of Pharmacology, School of Pharmacy Qingdao University Qingdao China
刊名: Thoracic Cancer, 2019, Vol.10 (3), pp.428-436
来源数据库: Wiley Journal
DOI: 10.1111/1759-7714.12944
关键词: ERK signalInvasionMigrationProliferationSQLE
原始语种摘要: Background(#br)The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal. We conducted this study to investigate the effect of SQLE expression on lung squamous cell carcinoma (SCC) proliferation, migration, and invasion and its role in extracellular signal‐regulated kinase (ERK) signaling.(#br)Methods(#br)Cell Counting Kit 8, wound healing, and Transwell assays; Western blotting; and quantitative real‐time PCR were used to investigate the effect of SQLE in a lung SCC H520 cell line. Kaplan–Meier analysis was used to identify the prognostic significance of SQLE.(#br)Results(#br)Overexpression of SQLE promoted lung SCC cell...
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关键词翻译
关键词翻译
  • squamous 具鳞的
  • carcinoma 癌症
  • signaling 发信号
  • regulated 规定
  • epoxidase 环氧酶
  • metastasis 同质蜕变
  • extracellular 胞外的
  • prognosis 预报
  • proliferation 增生
  • squalene 鲨鱼烯