Aerobic Baeyer–Villiger Oxidation Catalyzed by a Flavin‐Containing Enzyme Mimic in Water
作者: Yoan ChevalierYvette Lock Toy KiDr. Didier le NouenProf. Jean‐Pierre MahyProf. Jean‐Philippe GoddardDr. Frédéric Avenier
作者单位: 1Univ Paris Sud Université Paris Saclay LCBB, ICMMO, UMR CNRS 8182 91405 Orsay France
2 Université de Haute-Alsace Université de Strasbourg CNRS, LIMA UMR 7042 68100 Mulhouse France
刊名: Angewandte Chemie International Edition, 2018, Vol.57 (50), pp.16412-16415
来源数据库: Wiley Journal
DOI: 10.1002/anie.201810124
关键词: Baeyer–Villiger reactionEnzymesOxidationOxygen heterocyclesSustainable chemistry
原始语种摘要: Abstract(#br)Direct incorporation of molecular oxygen into small organic molecules has attracted much attention for the development of new environmentally friendly oxidation processes. In line with this approach, bioinspired systems mimicking enzyme activities are of particular interest since they may perform catalysis in aqueous media. Demonstrated herein is the incorporation of a natural flavin cofactor (FMN) into the specific microenvironment of a water‐soluble polymer which allows the efficient reduction of the FMN by NADH in aqueous solution. Once reduced, this artificial flavoenzyme can then activate molecular dioxygen under aerobic conditions and result in the Baeyer–Villiger reaction at room temperature in water.
全文获取路径: Wiley  (合作)

  • aqueous 水的
  • aerobic 需氧的
  • oxygen 
  • oxidation 氧化
  • perform 履行
  • reaction 反酌
  • reduction 减少
  • flavoenzyme 黄素酶
  • solution 溶液
  • conditions 条件式