Constitutive TNF‐α signaling in neonates is essential for the development of tissue‐resident leukocyte profiles at barrier sites
作者: Marie Sophie BickesSabine PirrAnna Sophie HeinemannBeate FehlhaberStephan HalleLena VöllgerMaike WillersManuela RichterCarolin BöhneMelanie AlbrechtMelissa LangerSandra PfeiferDanny JonigkGertrud VietenBenno UreConstantin KaisenbergReinhold FörsterMaren Köckritz-BlickwedeGesine HansenDorothee Viemann
作者单位: 1Department of Pediatric Pneumology, Allergology, and Neonatology Hannover Medical School Hannover Germany
2 Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC) Hannover Medical School Hannover Germany
3 Institute of Immunology Hannover Medical School Hannover Germany
4 Department of Pathology Hannover Medical School Hannover Germany
5 Department of Pediatric Surgery Hannover Medical School Hannover Germany
6 Department of Obstetrics and Gynecology Hannover Medical School Hannover Germany
7 Children's Hospital Auf der Bult Hannover Germany
8 Department of Physiological Chemistry Research Center for Emerging Infections and Zoonoses (RIZ) University of Veterinary Medicine Hannover Hannover Germany
刊名: The FASEB Journal, 2019, Vol.33 (10), pp.10633-10647
来源数据库: Wiley Journal
DOI: 10.1096/fj.201900796R
关键词: Newborn infantEndotheliumLeukocyte traffickingNeonatal immunitySepsis
原始语种摘要: ABSTRACT(#br)Newborn infants have a high disposition to develop systemic inflammatory response syndromes (SIRSs) upon inflammatory or infectious challenges. Moreover, there is a considerable trafficking of hematopoietic cells to tissues already under noninflammatory conditions. These age‐specific characteristics suggest a hitherto unappreciated crucial role of the vascular endothelium during the neonatal period. Here, we demonstrate that healthy neonates showed already strong endothelial baseline activation, which was mediated by a constitutively increased production of TNF‐α. In mice, pharmacological inhibition of TNF‐α directly after birth prevented subsequent fatal SIRS but completely abrogated the recruitment of leukocytes to sites of infection. Importantly, in healthy neonates,...
全文获取路径: Wiley  (合作)
影响因子:5.704 (2012)

  • leukocyte 白血球
  • essential 本质的
  • barrier 堡坝
  • disposition 配置
  • resident 驻留的
  • postnatal 出生后的
  • development 开发
  • signaling 发信号
  • unappreciated 未得到欣赏的
  • already 已经