CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils
作者: Xichen ZhengNaidong ZhangLong QianXuexiang WangPeng FanJiajie KuaiSiyang LinChangpeng LiuWen JiangSongbing QinHaifeng ChenYuhui Huang
作者单位: 1Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention Soochow University Suzhou Jiangsu China
2 Department of Cardiology, Fujian Provincial Clinical College Fujian Medical University Fuzhou Fujian China
3 Department of Immunology The University of Texas Southwestern Medical Center Dallas TX
4 Department of Radiotherapy The First Affiliated Hospital of Soochow University Suzhou Jiangsu China
刊名: International Journal of Cancer, 2020, Vol.146 (6), pp.1730-1740
来源数据库: Wiley Journal
DOI: 10.1002/ijc.32829
关键词: EosinophilsTumor vessel normalizationAnti‐CTLA4 therapyBreast cancer
原始语种摘要: Immune checkpoint blockade (ICB) has shown long‐term survival benefits, but only in a small fraction of cancer patients. Recent studies suggest that improved vessel perfusion by ICB positively correlates with its therapeutic outcomes. However, the underlying mechanism of such a process remains unclear. Here, we show that anti‐cytotoxic T‐lymphocyte‐associated protein 4 (CTLA4) treatment‐induced tumor vessel normalization was accompanied by an increased infiltration of eosinophils into breast tumors. Eosinophil accumulation was positively correlated with the responsiveness of a breast tumor to anti‐CTLA4 therapy. Depletion of eosinophils subsequently negated vessel normalization, reduced antitumor immunity and attenuated tumor growth inhibition by anti‐CTLA4 therapy. Moreover, intratumoral...
全文获取路径: Wiley  (合作)

  • normalization 正规化
  • accumulation 堆积
  • vessel 容器
  • breast 胸部
  • blockade 封闭
  • checkpoint 检查地点
  • growth 生长
  • antitumor 抗癌的
  • positively 断然
  • responsiveness 应答性