Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development
作者: S. Ozlem AltinkayaSumeyra N. AvciogluSelda D. SezerSerdar Ceylaner
作者单位: 1Department of Gynecology and Obstetrics Adnan Menderes University, Faculty of Medicine Aydin Turkey
2 Intergen Genetics Center Ankara Turkey
刊名: Journal of Obstetrics and Gynaecology Research, 2019, Vol.45 (10), pp.2088-2094
来源数据库: Wiley Journal
DOI: 10.1111/jog.14071
关键词: GenotypeLeiomyomaMutationPolymorphism
原始语种摘要: Abstract(#br)Aim(#br)The aim of the present study was to investigate the familial and somatic mutations as well as polymorphisms of TP53 gene in patients with uterine leiomyoma.(#br)Methods(#br)The study included 35 women with histologically diagnosed as uterine leiomyomas at the Gynecology Department of Adnan Menderes University Faculty of Medicine. Tissue and blood samples were analyzed for mutations and polymorphisms of TP53 gene by next generation sequencing (Miseq—Illumina). Acquired data was compared with the normal data in Ensembl database. Data from 1000 genome project and data from exome sequencing analyses in Intergen Genetic Diagnosis Center (Ankara) were used as controls for polymorphism analyses.(#br)Results(#br)There were no mutations in tissue and blood samples. However,...
全文获取路径: Wiley  (合作)

  • uterine 子宫的
  • leiomyoma 平滑肌瘤
  • associated 相关的
  • development 开发
  • controls 控制机构
  • polymorphism 多晶形
  • present 出席的
  • sequencing 排序
  • confidence 信用
  • database 资料库