Gamma‐amino butyric acid and the A‐type receptor suppress decidualization of mouse uterine stromal cells by down‐regulating cyclin D3
作者: Wenping LuoZhenzhen LiuDongmei TanQian ZhangHongying PengYingxiong WangYi Tan
作者单位: 1Laboratory Animal Center, Chongqing Medical University, Chongqing, China
2 Laboratory of Reproductive Biology, Chongqing Medical University, Chongqing, China
3 Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China.
刊名: Molecular Reproduction and Development, 2013, Vol.80 (1), pp.59-69
来源数据库: Wiley Journal
DOI: 10.1002/mrd.22137
原始语种摘要: Abstract(#br)Uterine decidualization, characterized by stromal cell proliferation and differentiation into polyploid decidual cells, is critical to the establishment of pregnancy in mice, although the mechanism underlying this process remains poorly understood. This study is the first to investigate the expression of gamma‐amino butyric acid (GABA) and the GABA A‐type receptor π subunit (GABPR) in the early‐pregnancy mouse uterus and their roles in decidualization. The expression of GABRP was detected from Day 4 to 8 of pregnancy. The effects of GABA and GABA A‐type receptor on cell proliferation and apoptosis were investigated using the Cell Titer 96® AQueous One Solution Cell Proliferation Assay and flow cytometry. The levels of cyclin D3 protein were measured in cultured stromal cells...
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关键词翻译
关键词翻译
  • receptor 接受体
  • Gamma 加马牌汽车
  • cyclin 细胞周期蛋白
  • cells 麻风细胞
  • uterine 子宫的
  • GABA 伽马氨基丁酸
  • mouse 小鼠
  • suppress 扼止
  • butyric 奶油的
  • stromal 基质的