Transcriptomics in tissue glucocorticoid sensitivity
作者: Nicolas C. NicolaidesAlexandros PolyzosEleni KoniariAgaristi LamprokostopoulouIfigeneia PapageorgiouEleni GolfinopoulouChrysanthi PapathanasiouAmalia SertedakiDimitris ThanosGeorge P. ChrousosEvangelia Charmandari
作者单位: 1Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics University of Athens Medical School "Aghia Sophia" Children's Hospital Athens Greece
2 Division of Endocrinology and Metabolism, Center for Clinical Experimental Surgery & Translational Research, Biomedical Research Foundation of the Academy of Athens Athens Greece
3 Institute of Molecular Biology, Genetics and Biotechnology Biomedical Research Foundation of the Academy of Athens Athens Greece
刊名: European Journal of Clinical Investigation, 2019, Vol.49 (8), pp.n/a-n/a
来源数据库: Wiley Journal
DOI: 10.1111/eci.13129
关键词: Glucocorticoid receptorGlucocorticoidsRNA sequencingTelomere lengthTissue glucocorticoid sensitivityTranscriptomics
原始语种摘要: Abstract(#br)Background(#br)Synthetic glucocorticoids are widely used in the treatment of several inflammatory, autoimmune and lymphoproliferative disorders. However, considerable variation in response to therapeutic doses of glucocorticoids has been documented among individuals. The aim of our study was to identify novel glucocorticoid sensitivity‐determining genes using genome‐wide expression profiling in healthy subjects.(#br)Methods(#br)One hundred one healthy subjects [mean age ± standard error of the mean (SEM); 26.52 ± 0.50 years] were given 0.25 mg dexamethasone at midnight, and serum cortisol concentrations were determined at 08:00 hours the following morning. Subjects were stratified into the 10% most glucocorticoid‐sensitive and 10% most glucocorticoid‐resistant according to...
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关键词翻译
关键词翻译
  • glucocorticoid 糖皮质激素
  • sensitivity 灵敏度
  • resistant 耐久的
  • cortisol 氢化可的松
  • lupus 豺狼座
  • dexamethasone 地塞米松
  • systemic 系统的
  • receptor 接受体
  • inflammatory 激怒的
  • healthy 健康的