Simple acute phase protein score to predict long‐term survival in patients with acute myeloid leukemia
作者: Alexander D. HeiniRebecca HugoMartin D. BergerUrban NovakUlrike BacherThomas Pabst
作者单位: 1Department of Medical Oncology University Hospital and University of Berne Berne Switzerland
2 Department of Hematology University Hospital and University of Berne| Berne Switzerland
3 Center of Laboratory Medicine, Inselspital University Hospital and University of Berne Berne Switzerland
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.74-81
来源数据库: Wiley Journal
DOI: 10.1002/hon.2696
关键词: Acute myeloid leukemiaAcute phase proteinAlbuminC‐reactive proteinFibrinogenPrognosisOutcome
原始语种摘要: Abstract(#br)High levels of acute phase reactants can be associated with adverse outcome in patients with various solid tumor types. For patients with acute myeloid leukemia (AML), this correlation is unknown. We retrospectively investigated the prognostic value of pretreatment acute phase protein levels in 282 consecutive newly diagnosed AML patients undergoing at least one cycle of intensive induction chemotherapy. We applied a new score integrating pre‐treatment C‐reactive protein (CRP), fibrinogen, and albumin levels termed the CFA ratio, and we stratified patients into two groups: Patients with a CFA ratio below 3.06 had decisively better progression‐free (26.2 vs 7.7 months; P < .001), disease‐free (56.4 vs 8.7 months; P < .001), and overall survival (61.2 vs 13.8 months; P < .001)....
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关键词翻译
关键词翻译
  • leukemia 白血病
  • myeloid 骨髓的
  • acute 急尖的
  • protein 蛋白质
  • survival 生存
  • score 得分
  • AML Micro Switch
  • chemotherapy 化学疗法
  • predict 预见
  • phase 相位