New biomarkers and therapeutic strategies in acute lymphoblastic leukemias: Recent advances
作者: Carolina SimioniFabio BergaminiMartina FerioliErika RimondiLorenzo CarusoLuca M. Neri
作者单位: 1Department of Medical Sciences University of Ferrara Ferrara Italy
2 Department of Morphology, Surgery and Experimental Medicine University of Ferrara Ferrara Italy
3 LTTA–Electron Microscopy Center University of Ferrara Ferrara Italy
4 Department of Biomedical and Surgical Sciences University of Ferrara Ferrara Italy
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.22-33
来源数据库: Wiley Journal
DOI: 10.1002/hon.2678
关键词: Acute lymphoblastic leukemiaBiTE antibodiesCAR‐TCRISPR‐Cas9ImmunotherapyTargeted therapy
原始语种摘要: Abstract(#br)Acute lymphoblastic leukemia (ALL) represents a heterogeneous group of hematologic malignancies, and it is normally characterized by an aberrant proliferation of immature lymphoid cells. Moreover, dysregulation of multiple signaling pathways that normally regulate cellular transcription, growth, translation, and proliferation is frequently encountered in this malignancy. ALL is the most frequent tumor in childhood, and adult ALL patients still correlate with poor survival. This review focuses on modern therapies in ALL that move beyond standard chemotherapy, with a particular emphasis on immunotherapeutic approaches as new treatment strategies. Bi‐specific T‐cell Engagers (BiTE) antibodies, the chimeric antigen receptor (CAR)‐T cells, or CRISPR‐Cas9 (clustered regularly...
全文获取路径: Wiley  (合作)

  • lymphoblastic 成淋巴细胞的
  • therapeutic 治疗的
  • acute 急尖的
  • leukemia 白血病
  • chemotherapy 化学疗法
  • malignancy 恶性
  • normally 标准状态
  • hematologic 血液学的
  • survival 生存
  • tailored 简明的