Detection of recurrent, rare, and novel gene fusions in patients with acute leukemia using next‐generation sequencing approaches
作者: Borahm KimEsl KimSeung‐Tae LeeJune‐Won CheongChuhl Joo LyuYoo Hong MinJong Rak Choi
作者单位: 1Department of Laboratory Medicine Yonsei University College of Medicine Seoul South Korea
2 Brain Korea 21 PLUS Project for Medical Science Yonsei University Seoul South Korea
3 Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea
4 Department of Pediatrics Yonsei University College of Medicine Seoul South Korea
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.82-88
来源数据库: Wiley Journal
DOI: 10.1002/hon.2709
关键词: Acute leukemiaNext‐generation sequencingRNA gene fusion detection
原始语种摘要: Abstract(#br)Identification of gene fusion is an essential part in the management of patients with acute leukemia, not only for diagnosis but also in predicting the treatment outcome and selecting appropriate treatment. Adopting next‐generation sequencing (NGS) technology for identification of gene fusion in patients with acute leukemia can be a good alternative to conventional tests. In the present study, the NGS RNA fusion gene panel test was applied to diagnostic samples of patients with acute leukemia to identify fusion genes more efficiently. Among 134 patients with acute leukemia, 53 gene fusions were detected in 52 patients. In addition to the recurrent gene fusions specified in the WHO diagnostic criteria, 11 rare or novel gene fusions were identified. Of those, two were gene...
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关键词翻译
关键词翻译
  • leukemia 白血病
  • rare 罕有
  • acute 急尖的
  • novel 长篇小说
  • generation 世代
  • recurrent 循环的
  • sequencing 排序
  • lymphoblastic 成淋巴细胞的
  • diagnostic 诊断的
  • fusion 融解