High intratumoural galectin‐1 expression predicts adverse outcome in ALK− ALCL and CD30+ PTCL‐NOS
作者: Johanne Marie HolstMaja LudvigsenStephen Jacques Hamilton‐DutoitKnud BendixTrine Lindhardt PlesnerPeter NørgaardMichael B. MøllerTorben SteinicheGabriel A. RabinovichFrancesco d'AmoreMartin Bjerregård Pedersen
作者单位: 1Department of Hematology Aarhus University Hospital Aarhus Denmark
2 Department of Clinical Medicine Aarhus University Aarhus Denmark
3 Department of Pathology Aarhus University Hospital Aarhus Denmark
4 Department of Pathology Herlev Hospital Herlev Denmark
5 Department of Pathology Odense University Hospital Odense Denmark
6 Institute of Biology and Experimental Medicine National Council of Scientific and Technical Investigations Buenos Aires Argentina
7 Department of Biological Chemistry, School of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.59-66
来源数据库: Wiley Journal
DOI: 10.1002/hon.2702
关键词: CD30Galectin‐1ImmunohistochemistryPeripheral T‐cell lymphomaPrognosis
原始语种摘要: Abstract(#br)Galectin‐1 (Gal‐1) has been associated with adverse prognosis in several cancers including lymphoma entities with CD30 expression. However, Gal‐1 expression has not been systematically assessed in peripheral T‐cell lymphomas (PTCL). Specimens from 169 nodal PTCL were assessed for intratumoural Gal‐1 expression by immunohistochemistry. Overall survival (OS) in groups exhibiting high and low Gal‐1 expression was compared in the cohort and in a subset analysis of CD30‐positive PTCL only. Gal‐1 expression was also correlated with biomarkers of the tumour microenvironment. No significant difference in OS based on Gal‐1 expression was observed in the entire PTCL cohort. However, in the CD30‐positive cohort, patients with high Gal‐1 levels had significantly poorer outcome (5 years...
全文获取路径: Wiley  (合作)

  • 特殊的 Not Otherwise Specified
  • expression 表示
  • NOS Not Otherwise Specified
  • PTCL Not Otherwise Specified
  • Gal 加仑
  • adverse 逆的
  • observed 观察到的
  • lymphoma 淋巴瘤
  • several 各自
  • cohort 伙伴
  • positive 阳片