Disease characteristics of diffuse large B‐cell lymphoma predicting relapse and survival after autologous stem cell transplantation: A single institution experience
作者: Daria GautTahmineh RomeroDavid OveisiGrant HowellGary Schiller
作者单位: 1Deparment of Medicine, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA
2 Division of General Internal Medicine and Health Services Research, Department of Medicine Statistics Core, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA
3 David Geffen School of Medicine University of California Los Angeles Los Angeles California USA
4 Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles Los Angeles California USA
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.38-50
来源数据库: Wiley Journal
DOI: 10.1002/hon.2690
关键词: Diffuse large B‐cell lymphomaAutologous stem cell transplantProgression‐free survivalOverall survivalInternational prognostic index
原始语种摘要: Abstract(#br)While various tools such as the International Prognostic Index (IPI) and its derivatives exist for risk‐stratification of diffuse large B‐cell lymphoma (DLBCL) at diagnosis, patient and disease characteristics capable of predicting outcome after high‐dose chemotherapy followed by autologous stem cell transplantation (HDC/ASCT) are not clearly defined. We retrospectively analyzed medical records of 111 DLBCL patients (78 relapsed and 33 refractory) who underwent HDC/ASCT at our institution from 2010‐2015. After a median follow‐up time of 4.6 years (interquartile range [IQR] 2.2‐8.1), the likelihood of 5‐year progression‐free survival (PFS) was 62.2% (95% CI, 53.4%‐72.4%) and the likelihood of 5‐year overall survival (OS) was 68.9% (95% CI, 60.7%‐78.2%). More than three...
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关键词翻译
关键词翻译
  • survival 生存
  • lymphoma 淋巴瘤
  • diffuse 普及
  • chemotherapy 化学疗法
  • predicting 预测
  • large 大的
  • experience 体验
  • institution 设立
  • refractory 耐火材料
  • International 国际的国际性组织