New responsibilities for aged kinases in B‐lymphomas
作者: Francesco PiazzaSabrina ManniArash ArjomandAndrea VisentinLivio TrentinGianpietro Semenzato
作者单位: 1Department of Medicine, Hematology and Clinical Immunology Branch University of Padova Padova Italy
2 Unit of Hematological Malignancies ‐ Laboratory of Myeloma and Lymphoma Pathobiology Foundation for Advanced Biomedical Research ‐ Veneto Institute of Molecular Medicine (FABR‐VIMM) Padova Italy
刊名: Hematological Oncology, 2020, Vol.38 (1), pp.3-11
来源数据库: Wiley Journal
DOI: 10.1002/hon.2694
关键词: B lymphocytesCK1CK2GSK3LymphomaProtein kinase
原始语种摘要: Abstract(#br)The knowledge accumulated over the last decade on B‐cell–derived non‐Hodgkin lymphoma (B‐NHL) pathogenesis has led to the identification of several molecular abnormalities, opening new perspectives in the design of novel therapies. Indeed, drugs targeting specific biochemical pathways critical for B‐NHL cell survival, proliferation, and fitness within the malignant microenvironment are now available to the clinician: the B‐cell receptor signaling inhibitors of BTK, PI3Kδ, ζ, γ, and SYK or the pro‐apoptotic BH3‐mimetics are clear examples of it. Moreover, it is emerging that malignant B‐cell growth is sustained not only by mutations in oncogenes/tumor suppressors but also by the “addiction” to nononcogene (ie, nonstructurally altered) molecules. In this regard, a consistent...
全文获取路径: Wiley  (合作)
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关键词翻译
关键词翻译
  • survival 生存
  • lymphoma 淋巴瘤
  • leukemia 白血病
  • targeting 导向目标
  • potential 
  • therapeutic 治疗的
  • malignant 恶性的
  • lymphocyte 淋巴细胞
  • decade 十进位
  • groundwork 基础