Intermolecular Aryl C−H Amination through Sequential Iron and Copper Catalysis
作者: Mohamed A. B. MostafaDr. Ewen D. D. CalderDr. Daugirdas T. RacysDr. Andrew Sutherland
作者单位: 1WestCHEM, School of Chemistry, The Joseph Black Building University of Glasgow University Avenue Glasgow G12 8QQ UK
刊名: Chemistry – A European Journal, 2017, Vol.23 (5), pp.1044-1047
来源数据库: Wiley Journal
DOI: 10.1002/chem.201605671
关键词: aminationbrominationcopper catalysiscross-couplingiron catalysis
原始语种摘要: Abstract(#br)A mild, efficient and regioselective method for para ‐amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one‐pot, two‐step procedure involving bromination of the aryl substrate with the powerful Lewis acid iron(III) triflimide, followed by a copper(I)‐catalysed N ‐arylation reaction. This two‐step dehydrogenative process for the regioselective coupling of aromatic C−H bonds with non‐activated amines was applicable to anisole‐, phenol‐, aniline‐ and acetanilide‐type aryl compounds. Importantly, the arene substrates were used as the limiting reagent and required no protecting‐group manipulations during the transformation.
全文获取路径: Wiley  (合作)
分享到:

×
关键词翻译
关键词翻译
  • amination 胺化
  • catalysis 催化
  • bromination 溴化
  • coupling 连接
  • arene 粗砂
  • anisole 茴香醚
  • bonds 公债
  • protecting 保护
  • arylation 芳基化
  • limiting 限制处理