Preparation of Highly Functionalized Grignard Reagents by an Iodine–Magnesium Exchange Reaction and its Application in Solid‐Phase Synthesis
作者: Laure BoymondMario RottländerGérard CahiezPaul Knochel
作者单位: 1Fachbereich Chemie der Universität, Hans‐Meerwein‐Strasse, D‐35032 Marburg (Germany), Fax: (+49) 6421‐282189
2 Ecole Supérieure de Chimie Organique et Minérale, Department de Chimie, 13, Boulevard de l′Hautil, F‐95092 Cergy‐Pontoise (France), Fax: (+33) 1‐4272‐2273
刊名: Angewandte Chemie International Edition, 1998, Vol.37 (12), pp.1701-1703
来源数据库: Wiley Journal
DOI: 10.1002/(SICI)1521-3773(19980703)37:12<1701::AID-ANIE1701>3.0.CO;2-U
关键词: CopperGrignard reactionsIodine–magnesium exchangeMagnesiumSolid‐phase synthesis
原始语种摘要: Abstract(#br)At −40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.
全文获取路径: Wiley  (合作)