Neurovascular Pathways and Alzheimer Amyloid β‐peptide
作者: Berislav V. ZlokovicRashid DeaneJan SallstromNienwen ChowJoseph M. Miano
作者单位: 1Frank P. Smith Laboratories for Neuroscience and Neurosurgical Research, Rochester, NY.
2 Socratech Research Laboratories, Rochester, NY.
3 Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY.
刊名: Brain Pathology, 2005, Vol.15 (1), pp.78-83
来源数据库: Wiley Journal
DOI: 10.1111/j.1750-3639.2005.tb00103.x
原始语种摘要: According to the prevailing amyloid cascade hypothesis, the onset and progression of a chronic neurodegenerative condition in Alzheimer disease (AD) is initiated by the amyloid β‐peptide (Aβ) accumulation in brain and consequent neuronal toxicity. Recent emphasis on co‐morbidity of AD and cerebrovascular disease and the recognition that cerebrovascular dysregulation is an important feature of AD, has shed new light on neurovascular dysfunction as a possible contributor to cognitive decline and Alzheimer neurodegeneration. In the same time, this association has raised a question as to whether there is a causal relationship between cerebrovascular dysregulation and Aβinitiated pathology, and whether influencing targets in the neurovasculature may prevent different forms of Aβ brain...
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