Human papillomavirus type 18 variants: Histopathology and E6/E7 polymorphisms in three countries
作者: Marjon A. De BoerLex A.W. PetersMohammed Farid AzizBudiningsih SiregarSantoso CornainM. Albert VredeEkaterina S. JordanovaGert Jan Fleuren
作者单位: 1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
2 Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
3 Division of Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
4 Department of Anatomic Pathology, Faculty of Medicine, Jakarta, Indonesia
5 Department of Pathology, Academic Hospital Paramaribo, Paramaribo, Suriname
6 Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Postbus 9600, 2300 RC Leiden, The Netherlands
刊名: International Journal of Cancer, 2005, Vol.114 (3), pp.422-425
来源数据库: Wiley Journal
DOI: 10.1002/ijc.20727
关键词: human papillomavirustype 18variantadenocarcinomacervical cancer
原始语种摘要: Abstract(#br)In cervical cancer, human papillomavirus type 18 (HPV 18) and HPV 16 are predominantly related to adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs), respectively. Here, we studied whether the geographically distributed HPV intratypic variants are also associated with histologically different tumors. A total of 44 HPV 18‐positive and 91 HPV 16‐positive cervical carcinomas from Indonesian, Surinamese and Dutch patients were histologically classified using hematoxilin and eosin, periodic acid Schiff plus and Alcian Blue staining. Samples were sequenced and intratypic variants were classified into the known phylogenetic branches. The Asian Amerindian HPV 18 variant was observed in 56% of ADCs compared to 15% of SCCs ( p < 0.006). The African HPV 18 variant was...
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