Neovascularization in an arterio‐venous loop‐containing tissue engineering chamber: role of NADPH oxidase
作者: F. JiangG. ZhangI. HashimotoB. S. KumarS. BortolottoW. A. MorrisonG. J. Dusting
作者单位: 1Bernard O’Brien Institute of Microsurgery, the University of Melbourne, Victoria, Australia
2 Department of Plastic and Reconstructive Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
刊名: Journal of Cellular and Molecular Medicine, 2008, Vol.12 (5b), pp.2062-2072
来源数据库: Wiley Journal
DOI: 10.1111/j.1582-4934.2008.00199.x
关键词: angiogenesisNADPH oxidaseredox signallingtissue engineering
原始语种摘要: Abstract(#br)Using an in vivo arterio‐venous loop‐containing tissue‐engineering chamber, we have created a variety of vascularized tissue blocks, including functional myocardium. The viability of the transplanted cells is limited by the rate of neovascularization in the chamber. A Nox2‐containing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is thought to have a critical role in ischaemic angiogenesis. In this study we investigated whether NADPH oxidase is involved in the neovascularization process in the tissue‐engineering chamber. New blood vessels originating from the venous and the arterial ends of the loop could be identified after 3 days, and the vessel density (by lectin staining) peaked after 7 days and was maintained for at least 14 days. This was accompanied by...
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