Positive effect of silymarin on cell growth and differentiation in bovine and murine mammary cells
作者: L. Starvaggi CucuzzaM. MottaS. MirettiE. MacchiE. MartignaniP. AccorneroM. Baratta
作者单位: 1Department of Veterinary Morphophysiology, University of Torino, Grugliasco, Italy
刊名: Journal of Animal Physiology and Animal Nutrition, 2010, Vol.94 (1), pp.111-117
来源数据库: Wiley Journal
DOI: 10.1111/j.1439-0396.2008.00890.x
关键词: silymarincell viabilitydifferentiationmammary epitheliumbovine
原始语种摘要: Summary(#br)Silymarin, a naturally acknowledged hepatoprotector used in humans to treat liver diseases has been tested in murine (HC11) and bovine (BME‐UV) mammary epithelial cell lines to evaluate a possible direct effect on cell growth and differentiation in mammary gland. Silymarin enhanced cell proliferation (p < 0.05) from 10 to 1000 ng/ml in association with growth factors, (up to 20%) or alone (up to 15%) versus controls. Furthermore, silymarin (100 ng/ml) was able to increase (p < 0.05) β‐casein gene expression alone or in association with prolactin (5 μg/ml). These effects may be related with protein kinase B (AKT) activation induced by silymarin treatment (p < 0.05) and/or by a dose‐related inhibitory effect (p < 0.05) on caspase‐3 activity related to a protective role in cell...
全文获取路径: Wiley  (合作)

  • mammary 乳房的
  • silymarin 水飞蓟素
  • effect 效应
  • murine 鼠灰色
  • growth 生长
  • gland 
  • bovine 牛的
  • cells 麻风细胞
  • association 联合
  • treat 处理