Pure non‐gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis
作者: Hyun‐Lyoung KooJene ChoiKyu‐Rae KimJong‐Hyuk Kim
作者单位: 1Departments of Pathology and
2 Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
刊名: Pathology International, 2006, Vol.56 (10), pp.613-616
来源数据库: Wiley Journal
DOI: 10.1111/j.1440-1827.2006.02016.x
关键词: choriocarcinomaDNA polymorphismnon‐gestationalovary
原始语种摘要: Pure primary ovarian choriocarcinoma is a rare condition that can be of gestational or non‐gestational origin. Non‐gestational choriocarcinoma has been found to be resistant to single‐agent chemotherapy and has a worse prognosis than gestational choriocarcinoma, but it is difficult to distinguish the two types by routine histological examination. Herein is reported a case of primary pure non‐gestational choriocarcinoma of the ovary in a 33‐year‐old nulligravid woman, as confirmed by DNA polymorphism analysis. All tested microsatellite markers had identical DNA profiles with the same allelic sizes between the tumor and the myometrium of the patient, who was homozygous for three markers (BAT26, BAT25 and D17S250) and heterozygous for four (D2S123, D18S57, DCC and D18S58), supporting...
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