A case of idiopathic pulmonary alveolar proteinosis accompanied by T‐cell receptor gene rearrangement in bronchoalveolar lavage fluid cells
作者: Takeshi HOSOKAWAEtsuro YAMAGUCHIShinya SHIRAISatoshi FUKEKazuo TAKAOKAJun‐ichiro KOJIMAKoh NAKATAMasaharu NISHIMURA
作者单位: 1First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido
2 Department of Respiratory Medicine and Allergology, Aichi Medical University, Nagakute, Aichi
3 Department of Internal Medicine, Sapporo Social Insurance General Hospital, Sapporo, Hokkaido
4 Iwamizawa Rosai Hospital, Iwamizawa, Hokkaido
5 Department of Respiratory Disease, Research Institute, International Medical Center of Japan, Tokyo, Japan
刊名: Respirology, 2004, Vol.9 (2), pp.286-288
来源数据库: Wiley Journal
DOI: 10.1111/j.1440-1843.2004.00574.x
关键词: pulmonary alveolar proteinosisgranulocyte‐macrophage colony stimulating factorantigranulocyte‐macrophage colony stimulating factor antibodygene rearrangement
原始语种摘要: Abstract: We describe a case of a patient with idiopathic pulmonary alveolar proteinosis (PAP), who had an elevated serum level of antigranulocyte‐macrophage colony stimulating factor (anti‐GM‐CSF) antibody accompanied by T‐cell receptor gene rearrangements in BAL fluid cells. Histopathological examination of the lung excluded lymphoma but revealed PAP and silicosis. There was no detectable serum anti‐GM‐CSF antibody in 50 outpatients with advanced silicosis who did not have PAP, suggesting that anti‐GM‐CSF antibody is directly linked to PAP but not to silicosis. We speculate that monoclonal expansion of a T‐cell population may play a role in the production of anti‐GM‐CSF antibody and the development of PAP.
全文获取路径: Wiley  (合作)
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关键词翻译
关键词翻译
  • proteinosis 蛋白沉积
  • alveolar 蜂窝状
  • pulmonary 肺的
  • lavage 灌洗
  • silicosis 硅肺
  • rearrangement 重新配置
  • PAP PORT-AU-PRINCE
  • stimulating 促进
  • antibody 抗体
  • macrophage 巨噬细胞