Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii
作者: Gang DingHailou WangLi LiAmanda Juan ChenLin ChenHong ChenHongwu ZhangXinzhong LiuZhongmei Zou
作者单位: 1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P. R. China, Fax: +86‐10‐57833290
2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China
3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China
4 Medical College of Chinese People's Armed Police Force, Tianjin 300162, P. R. China
5 Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P. R. China
刊名: European Journal of Organic Chemistry, 2012, Vol.2012 (13), pp.2516-2519
来源数据库: Wiley Journal
DOI: 10.1002/ejoc.201200053
关键词: Structure elucidationNatural productsCytotoxicityConfiguration determination
原始语种摘要: Abstract(#br)Two new cytochalasans, trichoderones A ( 1 ) and B ( 2 ), and three known analogues, aspochalasins D ( 3 ), J ( 4 ), and I ( 5 ), were isolated from the endophytic fungus Trichoderma gamsii . Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A ( 1 ) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B ( 2 ) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12‐oxatricyclo [6.3.1.02,7] moiety.
全文获取路径: Wiley  (合作)
分享到:
来源刊物:
影响因子:3.344 (2012)

×
关键词翻译
关键词翻译
  • Trichoderma 生菌散
  • pentacyclic 五轮列的
  • determination 测定
  • endophytic 内部生长的
  • unprecedented 前所未有的
  • cytotoxic 细胞毒素的
  • moiety 一部分
  • fungus 真菌
  • products 制品
  • elucidation 阐明