KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation
作者: Kristian IkenbergNadejda ValtchevaSimone BrandtQing ZhongChristine E WongAurelia NoskeMarkus RechsteinerJan H RueschoffRosmarie CaduffAthanassios DellasEllen ObermannDaniel FinkThomas FuchsWilhelm KrekHolger MochIan J FrewPeter J Wild
作者单位: 1Institute of Surgical Pathology University Hospital Zurich Zurich Switzerland
2 Krebsliga beider Basel Basel Switzerland
3 Institute of Pathology University Hospital of Basel Basel Switzerland
4 Department of Gynecology University Hospital Zurich Zurich Switzerland
5 Department of Electrical Engineering California Institute of Technology Pasadena CA USA
6 Institute of Cell Biology ETH Zurich Zurich Switzerland
7 Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland
刊名: The Journal of Pathology, 2014, Vol.234 (2), pp.239-252
来源数据库: Wiley Journal
DOI: 10.1002/path.4390
关键词: KPNA2importinendometrial cancerbiomarkerEMTSnail
原始语种摘要: Abstract(#br)Endometrial cancer is the most frequently occurring malignancy of the female genital tract in Western countries. Although in many cases surgically curable, about 30% of the tumours represent an aggressive and untreatable disease. In an attempt to establish a reliable prognostic marker for endometrial carcinomas disregarding their histological diversity, we investigated the expression of KPNA2 , a mediator of nucleocytoplasmic transport, and other cell proliferation‐associated proteins and their correlation with cancer progression. We analysed patient tissue microarrays ( TMAs ) assembled from 527 endometrial cancer tissue specimens and uterus samples from a Trp53 knockout mouse model of endometrial cancer. Our data show that KPNA2 expression was significantly up‐regulated in...
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