Nanosuspension Development of Scutellarein as an Active and Rapid Orally Absorbed Precursor of its BCS Class IV Glycoside Scutellarin
作者: Xiao YangXiaoqing MiaoFangrui CaoShang LiNana AiQi ChangSimon M. Y. LeeYing Zheng
作者单位: 1State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Science University of Macau Macao China
2 Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China
刊名: Journal of Pharmaceutical Sciences, 2014, Vol.103 (11), pp.3576-3584
来源数据库: Wiley Journal
DOI: 10.1002/jps.24149
关键词: Scutellarin (SG)PrecursorNanotechnologyOral drug deliverySolubilityMetabolismAbsorptionZebrafishCerebral hemorrhage
原始语种摘要: This work addressed solubility and membrane permeability problems of Biopharmaceutics Classification System ( BCS ) Class IV glycoside scutellarin ( SG ) by developing a nanosuspension of its aglycone scutellarein ( S ) as a precursor. An S nanosuspension containing poloxamer 188 was prepared using antisolvent precipitation where hydroxypropyl‐β‐cyclodextrin was utilized as a lyophilizing protectant. Particle size and polydispersity index after redispersion were 342.6 ± 18.2 and 0.32 ± 0.06 nm, respectively. The dissolution rate of the S nanosuspension was superior compared with the physical mixture. No free S , but SG and SG 's isomer were detected in plasma following oral delivery of SG or S , S nanosuspension or physical mixture of S . The C max values of SG after dosing...
全文获取路径: Wiley  (合作)
影响因子:3.13 (2012)

  • aglycone 配质
  • BCS Basic Catalog Structure
  • developing 显影
  • physical 物理的
  • scutellarein 黄芩配基
  • glycoside 配糖体
  • Class B类放大器、 C类放大器
  • dosing 配量
  • scutellarin 黄芩素
  • flavonoid 黄酮类