Chloroacetate‐Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis
作者: Dr. Jianming LiuXin ZhangHong YiDr. Chao LiuRen LiuDr. Heng ZhangProf. Dr. Kelei ZhuoProf. Dr. Aiwen Lei
作者单位: 1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P. R. China)
2 Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007 (P. R. China)
刊名: Angewandte Chemie International Edition, 2015, Vol.54 (4), pp.1261-1265
来源数据库: Wiley Journal
DOI: 10.1002/anie.201409580
关键词: copper catalysisethyl chloroacetateN‐heterocyclesselective oxidations
原始语种摘要: Abstract(#br)The efficient selective oxidation and functionalization of CH bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl chloroacetate as a promoter. In this transformation, various substituted N‐heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N‐heterocyclic compounds and ethyl chloroacetate work synergistically to activate CH bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.
全文获取路径: Wiley  (合作)

  • heterocyclic 杂环的
  • ethyl 乙基
  • bonds 公债
  • catalysis 催化
  • methylene 甲叉
  • mechanistic 机械的
  • selective 选择性的
  • substituted 取代的
  • catalyst 催化剂
  • compounds 化合物