Maternal high‐fat diet exposure leads to insulin resistance and impacts myogenic and adipogenicgene expression in offspring rats
作者: Xiao YangPeng LaiXiang‐Gui ChenZhen‐Ping LiuYuan‐Mou TangSu RaoChun‐Juan WenShi‐Rong JiaoJi Lei
作者单位: 1School of Bioengineering Xihua University Chengdu P. R. China
刊名: European Journal of Lipid Science and Technology, 2015, Vol.117 (10), pp.1550-1560
来源数据库: Wiley Journal
DOI: 10.1002/ejlt.201400421
关键词: AdipogenesisInsulin resistanceMaternal high‐fat diet exposureMyogenesisOffspring
原始语种摘要: To obtain information on the molecular mechanisms of insulin resistance (IR) in offspring rats due to maternal high‐fat diet exposure, we investigated (i) the consequences of maternal high‐fat diet consumption on offspring malprogramming that predisposes the offspring to the onset of IR during adulthood and (ii) the impact of a maternal high‐fat diet on myogenic and adipogenic gene expression in muscle. Sprague–Dawley female rats were randomly divided into two groups and fed either a normal chow (NC) or a high‐fat diet (HF). After breeding, the pups were divided into four groups: male offspring of HF (MOH), female offspring of HF (FOH), male offspring of NC (MON) and female offspring of NC (FON). The offspring rats were fed NC until 18 weeks after weaning. The body weight, plasma...
全文获取路径: Wiley  (合作)

  • offspring 后代
  • expression 表示
  • myogenic 肌原性的
  • insulin 胰岛素
  • exposure 暴露
  • leads 引线
  • maternal 母的
  • divided 分部联箱
  • adipogenic 生脂的
  • female 女性的