Comparative proteomic analysis of the ATP ‐sensitive K <sup>+</sup> channel complex in different tissue types
作者: Eirini KefaloyianniJohn S. LyssandCesar MorenoDiane DelarocheMiyoun HongDavid FenyöCharles V. MobbsThomas A. NeubertWilliam A. Coetzee
作者单位: 1Pediatrics NYU School of Medicine New York NY USA
2 Kimmel Center for Biology and Medicine at the Skirball Institute NYU School of Medicine New York NY USA
3 Fishberg Center for Neurobiology Mount Sinai School of Medicine New York NY USA
4 Center for Health Informatics and Bioinformatics NYU School of Medicine New York NY USA
5 Biochemistry and Molecular Pharmacology NYU School of Medicine New York NY USA
6 Physiology and Neuroscience NYU School of Medicine New York NY USA
刊名: PROTEOMICS, 2013, Vol.13 (2), pp.368-378
来源数据库: Wiley Journal
DOI: 10.1002/pmic.201200324
关键词: Cell biologyESI ‐ MS / MSHeart proteinsIdentificationMultiprotein complexWestern blots
原始语种摘要: ATP ‐sensitive K + ( K ATP) channels are expressed ubiquitously, but have diverse roles in various organs and cells. Their diversity can partly be explained by distinct tissue‐specific compositions of four copies of the pore‐forming inward rectifier potassium channel subunits ( K ir6.1 and/or K ir6.2) and four regulatory sulfonylurea receptor subunits ( SUR 1 and/or SUR 2). Channel function and/or subcellular localization also can be modified by the proteins with which they transiently or permanently interact to generate even more diversity. We performed a quantitative proteomic analysis of K ATP channel complexes in the heart, endothelium, insulin‐secreting min6 cells (pancreatic β‐cell like), and the hypothalamus to identify proteins with which they...
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