Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis
作者: Masahiro FukuyamaYohei SatoYoshimi YamazakiManabu Ohyama
作者单位: 1Department of Dermatology Kyorin University School of Medicine Tokyo Japan
刊名: Journal of Cutaneous Pathology, 2017, Vol.44 (10), pp.861-866
来源数据库: Wiley Journal
DOI: 10.1111/cup.12992
关键词: cystic panfolliculomaepithelial‐mesenchymal interactionsimmunohistochemical studytrichofolliculoma
原始语种摘要: Panfolliculoma ( PF ) is a rare benign tumor with signs of differentiation toward all components of the hair follicle ( HF ). Cystic panfolliculoma ( CPF ) is a subset of PF with histological similarity to trichofolliculoma making the differential diagnosis difficult in some cases. Immunohistopathological investigations of PF have been reported; however, previous studies focused mostly on the expression profile of the outer root sheath markers. Herein, we report a case of CPF. A panel of antibodies was developed and used for the detection of the expression of cytokeratin ( CK ) 10, CK13 , CK14 , CK15 , hair‐hard keratin ( AE13 ) and EpCAM within the lesion, supporting the differentiation of all epithelial lineages of the HF and the diagnosis of CPF . Immunohistopathological examinations...
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