Abdominal adiposity is not a mediator of the protective effect of Mediterranean diet on colorectal cancer
作者: Francesca FasanelliDaniela ZugnaMaria Teresa GiraudoVittorio KroghSara GrioniSalvatore PanicoAmalia MattielloGiovanna MasalaSaverio CainiRosario TuminoGraziella FrascaVeronica SciannameoFulvio RicceriCarlotta Sacerdote
作者单位: 1Unit of Cancer Epidemiology, Department of Medical Sciences University of Turin and Città della Salute e della Scienza University‐Hospital Center for Cancer Prevention (CPO) Turin Italy
2 Department of Mathematics University of Turin Turin Italy
3 Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
4 Department of Clinical Medicine and Surgery Federico II University Naples Italy
5 Cancer Risk Factors and Lifestyle Epidemiology Unit Cancer Research and Prevention Institute – ISPO Florence Italy
6 Cancer Registry, Department of Prevention ASP Ragusa Italy
7 Unit of Epidemiology, Regional Health Service, Grugliasco Turin Italy
8 Department of Clinical and Biological Sciences University of Turin Orbassano (Torino) Italy
刊名: International Journal of Cancer, 2017, Vol.140 (10), pp.2265-2271
来源数据库: Wiley Journal
DOI: 10.1002/ijc.30653
原始语种摘要: Adherence to the Mediterranean diet (MD) has a preventive effect on colorectal cancer (CRC). Several biological mechanisms have been hypothesized to explain this effect, but the involvement of clinical mediators has not been experimentally proven. We examined the role of abdominal adiposity (i.e., waist‐to‐hip ratio, WHR) as a potential mediator of the relationship between the MD and CRC in the Italian centres of the European Prospective Investigation into Cancer and Nutrition. We evaluated the effect of the Italian Mediterranean Index (IMI) on WHR and of WHR on CRC risk. We then estimated the natural indirect effect (NIE, mediated by WHR) and the pure direct effect (PDE, unmediated) of IMI on CRC risk using mediation analyses, considering age, sex, education, physical activity, smoking...
全文获取路径: Wiley  (合作)