Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing
作者: Nicola FuscoPierre‐Emmanuel ColomboLuciano G MartelottoMaria R De FilippoSalvatore PiscuoglioCharlotte K Y NgRaymond S LimWilliam JacotAnne Vincent‐SalomonJorge S Reis‐FilhoBritta Weigelt
作者单位: 1Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA
2 School of Pathology University of Milan Milan Italy
3 Department of Surgical Oncology Montpellier Cancer Institute (ICM) Montpellier France
4 Department of Tumor Biology Institut Curie Paris France
刊名: Histopathology, 2016, Vol.68 (2), pp.262-271
来源数据库: Wiley Journal
DOI: 10.1111/his.12735
关键词: adenoid cystic carcinomabreast cancercylindromafluorescence in‐situ hybridizationmassively parallel sequencing
原始语种摘要: Aims(#br)The aims of this study were to perform a whole‐exome sequencing analysis of a breast cylindroma and to investigate the role of molecular analyses in the differentiation between breast cylindroma, a benign tumour that displays MYB expression, and CYLD gene mutations, and its main differential diagnosis, the breast solid‐basaloid adenoid cystic carcinoma, a malignant tumour that is characterized by the presence of the MYB–NFIB fusion gene and MYB overexpression.(#br)Methods and results(#br)A 66‐year‐old female underwent quadrantectomy after an irregular dense shadow was discovered in the right breast at the screening mammogram. Histologically, the tumour displayed features suggestive of a solid‐basaloid variant of adenoid cystic carcinoma with a differential diagnosis of...
全文获取路径: Wiley  (合作)
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