Micro RNA Let‐7b inhibits keratinocyte migration in cutaneous wound healing by targeting IGF 2 BP 2
作者: Yan WuJulia Li ZhongNing HouYaolan SunBenting MaMuhammad Farrukh NisarYan TengZhaoli TanKeping ChenYouliang WangXiao Yang
作者单位: 1State Key Laboratory of Proteomics Genetic Laboratory of Development and Diseases Institute of Biotechnology Beijing China
2 111 Project Laboratory of Biomechanics and Tissue Repair College of Bioengineering & Key Laboratory of Biorheological Science and Technology Ministry of Education Chongqing University Chongqing China
3 College of Life Sciences Jiangsu University Zhenjiang China
刊名: Experimental Dermatology, 2017, Vol.26 (2), pp.116-123
来源数据库: Wiley Journal
DOI: 10.1111/exd.13164
关键词: IGF 2 BP 2keratinocytemicro RNA let‐7bmigrationwound healing
原始语种摘要: Abstract(#br)Wound healing is a complex process which involves proliferation and migration of keratinocyte for closure of epidermal injuries. A member of micro RNA family, let‐7b, has been expressed in mammalian skin, but its exact role in keratinocyte migration is still not in knowledge. Here, we showed that let‐7b regulates keratinocyte migration by targeting the insulin‐like growth factor IGF 2 BP 2. Overexpression of let‐7b led to reduced HaCaT cell migration, while knockdown of let‐7b resulted in enhanced migration. Furthermore, let‐7b was decreased during wound healing in wild‐type mice, which led us to construct the transgenic mice with overexpression of let‐7b in skin. The re‐epithelialization of epidermis of let‐7b transgenic mice was reduced during wound healing. Using...
全文获取路径: Wiley  (合作)

  • migration 迁移
  • keratinocyte 角化细胞
  • healing 加硫
  • targeting 导向目标
  • wound 
  • member 
  • micro 
  • bioinformatics 生物信息学
  • knockdown 击倒