Internal Oxidant‐Triggered Aerobic Oxygenation and Cyclization of Indoles under Copper Catalysis
作者: Dr. Huawen HuangJinhui CaiDr. Xiaochen JiDr. Fuhong XiaoYa ChenProf. Dr. Guo‐Jun Deng
作者单位: 1Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105 (China)
刊名: Angewandte Chemie International Edition, 2016, Vol.55 (1), pp.307-311
来源数据库: Wiley Journal
DOI: 10.1002/anie.201508076
关键词: aerobic oxygenationcopper catalysiscyclizationindolesinternal oxidants
原始语种摘要: Abstract(#br)A concise synthesis of pyrazolo[1,5‐a]indole derivatives by copper‐catalyzed aerobic oxygenation and cyclization of indoles with oxime acetates is described. This protocol represents an elegant example of N‐1, C‐2, and C‐3 tri‐functionalization of indoles in one‐pot. Mechanistic studies indicate the reaction proceeds through a radical procedure. Oximes as an internal oxidant have been demonstrated to be a driver to initiate aerobic oxidation, which provides a new oxidative pattern for C‐H functionalization even with high atom‐ and step‐economy.
全文获取路径: Wiley  (合作)
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