Specific Photothermal Ablation Therapy of Endometriosis by Targeting Delivery of Gold Nanospheres
作者: Xiaomeng GuoWei LiJialin ZhouWanqing HouXue WenHanbo ZhangFenfen KongLihua LuoQingpo LiYongzhong DuJian You
作者单位: 1College of Pharmaceutical Sciences Zhejiang University 866 Yuhangtang Road Hangzhou Zhejiang 310058 P. R. China
2 Zhejiang Center for Drug and Cosmetic Evaluation 39 Yile Road Hangzhou Zhejiang 310012 P. R. China
3 Department of Pathology The First Affiliated Hospital Zhejiang University School of Medicine 79 Qingchun Road Hangzhou Zhejiang 310006 P. R. China
刊名: Small, 2017, Vol.13 (15), pp.n/a-n/a
来源数据库: Wiley Journal
DOI: 10.1002/smll.201603270
关键词: endometriosisenhanced permeability and retentionEphB4 receptorhollow gold nanospheresphotothermal ablation therapy
原始语种摘要: Endometriosis is difficult to treat since the side effects of the current therapeutic method and the high recurrence rate; thus, newer and safer therapeutic approaches are urgently needed. This work investigates the enhanced permeability and retention effect of CdTe quantum dots (QDs) and hollow gold nanospheres (HAuNS) in endometriosis to increase the delivery of HAuNS into lesion cells. The surface of HAuNS is successfully conjugated with a TNYL peptide that has specific affinity for the EphB4 receptor, which is a member of the Eph family of receptor tyrosine kinases. It is found that the EphB4 receptor is overexpressed in endometriosis lesions. The data indicate that both QDs and HAuNS can efficiently accumulate in endometriotic lesions through permeable vessels and the TNYL‐conjugated...
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