ANTICONVULSANT ACTIVITY OF ISONICOTINIC ACID HYDRAZONE DERIVATIVES USING MES, scPTZ AND ROTOROD NEUROTOXICITY MODELS
作者: Sinha R Singh UVS Khosa RL Jain J
刊名: Journal of Applied Pharmaceutical Sciences and Research, 2018, Vol.1 (1)
来源数据库: KCS Publishers
DOI: 10.31069/japsr.v1i01.13058
关键词: Aryl acid HydrazoneAnticonvulsant ActivityIsonicotinic acid hydrazone
原始语种摘要: Introduction: Epilepsy is a chronic neurological disorder, involving group of nerve cells, or neurons, in the brain. Many classes of antiepileptic drugs are being prescribed and used by the stake holders but most of them are associated with serious side effects and toxicity. There is a strong need of new antiepileptic molecules with less side effects and toxicity. Objective: A series of aryl acid hydrazones of Isonicotinic acid hydrazide (RINH1 -RINH14) were synthesized and evaluated for Anticonvulsant activity. Material and Method: Compounds (RINH1 -RINH14) were synthesized by refluxing Isonicotinic acid hydrazide with different substituted benzaldehydes/ substituted acetophenones in absolute ethanol. Melting points of all synthesized compounds were monitored by open glass-capillary tube...
全文获取路径: PDF下载  JAPSR  (合作)
分享到:

×
关键词翻译
关键词翻译
  • antiepileptic 镇痫剂
  • anticonvulsant 镇痉剂
  • neurotoxicity 神经中毒性
  • potential 
  • hydrazone 
  • nerve 叶脉
  • activity 活度
  • capillary 毛状的
  • ethanol 乙醇
  • serious 认真的