DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL PATCH OF TIMOLOL MALEATE
作者: Sharma K Khan AD Sachdeva M
刊名: Journal of Applied Pharmaceutical Sciences and Research, 2018, Vol.1 (1)
来源数据库: KCS Publishers
DOI: 10.31069/japsr.v1i01.13057
关键词: Buccal patchesTimolol maleateMucosaSolvent casting technique
原始语种摘要: Introduction: The oral transmucosal Timolol maleate delivery bypasses liver and avoids presystemic elimination in the gastro intestinal tract and liver which enhance the bioavailability as well decreases the adverse effect. Objective: The present investigation highlights the formulation and evaluation of mucoadhesive buccal patch of Timolol maleate because Timolol maleate has biphasic solubility hence relatively permeated through buccal mucosa, which is well supplied with both vascular and lymphatic drainage. Material and Method: The mucoadhesive buccal patches of Timolol maleate were prepared by solvent casting technique using polymers like Hydroxypropylmethyl cellulose-15cps and Polyvinyl pyrrolidone. The formulated films were evaluated for their physiochemical parameters like surface...
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关键词翻译
关键词翻译
  • maleate 马来酸盐
  • formulation 配方
  • controlled 受控
  • buccal 口的
  • release 释放
  • cellulose 纤维素
  • physiochemical 生物化学的
  • percentage 百分数
  • permeation 渗透
  • biphasic 双相的