An Approach of Developing Floating Tablet of Lisinopril
作者: Nidhi JainRahul Gupta
作者单位: 1Department of Pharmacy, Barkatullah University, Bhopal, Madhya Pradesh462026, India.
刊名: Current Research in Pharmaceutical Sciences, 2016, pp.86-92
来源数据库: Empro Publications
原始语种摘要: Lisinopril is an antihypertensive agent with 12 hr half life, pH-dependent solubility, and narrow absorption window. So, the present study aimed to prolong its gastric residence time that entailed a development of an optimized gastro retentive floating tablets (GRFTs). The tablets were fabricated by direct compression using hydroxypropyl methylcellulose and carbopol 934 as release retarding polymers. The quality attributes of the tablets were evaluated. The buoyancy lag time, total floating time, swelling ability and in vitro release studies were al so carried out in 0.1 N HCl (pH 1.2) at 37 ± 0.5 °C. Statistical data analysis revealed that the optimized formulation containing 21.91% HPMC and 15% carbopol 934 had acceptable hardness, optimum floating behavior and 24h controlled-release...

  • carbopol 聚羰乙烯
  • tablets 平片体
  • floating 浮动的
  • controlled 受控
  • release 释放
  • solubility 溶度
  • formulation 配方
  • availability 有效度
  • development 开发
  • entailed 限定继承