Effectiveness of Cytoprotective Agents on Sulfur Mustard Induced Toxicity: The In vitro Model
作者: Alka GuptaR N GuptaG M KannanPankaj GuptaR Vijayaraghavan
作者单位: 1Department of Pharmacy, S.N. Medical College, Agra (U.P.)-India. alka0207@gmail.com
刊名: Current Research in Pharmaceutical Sciences, 2019, pp.278-284
来源数据库: Empro Publications
原始语种摘要: Sulphur mustard (bis (2-chloroethyl) sulfide, SM) is a powerful vesicating chemical warfare agent that causes profound injuries to the eyes, lungs and skin. Despite intensive research following the first use of SM in World War I, there is still no useful pretreatment or therapeutic antidote available. This agent remains a constant chemical threat. A potential approach to combating the debiliting effects of this agent is the use of compounds that can react with this material before it interacts with critical macromolecules. Glutathione (GSH), a tripeptide that exists in high concentrations in cells, reacts with SM and is involved in SM detoxification. Amifostine is a synthetic aminothiol, has been extensively used as a radioprotector. This prompted us to evaluate the protective efficacy of...
全文获取路径: Empro出版社 

  • chemical 化学的
  • compounds 化合物
  • above 在上面
  • mustard 芥末
  • constant 常数
  • aminoethyl 氨乙酸
  • radioprotector 放射保护剂
  • decrease 减少
  • before 在前面
  • concentrations 浓聚物