Formulation and Evaluation of Mesalamine Loaded pH Dependent Colon Specific Pulsatile Drug Delivery System
作者: Pravin PawarGharge Varsha
作者单位: 1Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India-415015.
刊名: Current Research in Pharmaceutical Sciences, 2018, pp.244-253
来源数据库: Empro Publications
原始语种摘要: The aim of these research of an oral colon specific, pulsatile device to attain time and or site specific release of Mesalamine, based on chronopharmaceutical consideration. The basic design consists of an insoluble hard gelatin capsule body, filled with Eudragit microcapsules of Mesalamine and sealed with a hydrogel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The Mesalamine microcapsules were prepared in three batches, with Eudragit L-100 and S-100 (1:2) by changing drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule....
全文获取路径: Empro出版社 

  • hydrogel 水凝胶
  • microcapsules 微囊剂
  • capsule 胶囊
  • release 释放
  • gelatin 
  • device 装置
  • specific 
  • maintain 
  • colon 结肠
  • overcome 克服