Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation
作者: Xiang-Yang ZhangFeng LiuYan ChenWei-Chun GuoZhao-Hui Zhang
作者单位: 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei Province
2Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province
刊名: Neural Regeneration Research, 2020, Vol.15 (6), pp.1066-1070
来源数据库: Wolters Kluwer Journal
DOI: 10.4103/1673-5374.270314
原始语种摘要: Brain-derived neurotrophic factor (BDNF) has robust effects on synaptogenesis, neuronal differentiation and synaptic transmission and plasticity. The maturation of BDNF is a complex process. Proprotein convertase 1/3 (PC1/3) has a key role in the cleavage of protein precursors that are directed to regulated secretory pathways; however, it is not clear whether PC1/3 mediates the change in BDNF levels caused by ischemia. To clarify the role of PC1/3 in BDNF maturation in ischemic cortical neurons, primary cortical neurons from fetal rats were cultured in a humidified environment of 95% N2 and 5% CO2 in a glucose-free Dulbecco’s modified Eagle’s medium at 37°C for 3 hours. Enzyme-linked immunosorbent assays and western blotting showed that after oxygen-glucose...
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影响因子:0.144 (2012)

  • deprivation 丧失
  • glucose 葡萄糖
  • neurotrophic 神经营养的
  • convertase 转化酶
  • cortical 皮层的
  • derived 导生的
  • induced 感应的
  • oxygen 
  • brain 
  • maturation 成熟