Overexpression of Cyclic Adenosine Monophosphate Effluent Protein MRP4 Induces an Altered Response to β-Adrenergic Stimulation in the Senescent Rat Heart
作者: Aude CarillionSarah FeldmanCheng JiangFabrice AtassiNa NaNathalie MougenotSophie BesseJean-Sébastien HulotBruno RiouJulien Amour
作者单位: 1From the Sorbonne Universités UPMC Univ Paris 06, UMR INSERM-UPMC 1166, Paris, France (A.C., S.F., C.J., F.A., N.M., J.-S.H., B.R., J.A.); Department of Anesthesiology and Critical Care Medicine (A.C., J.A.), Department of Emergency Medicine and Surgery (N.N., B.R.), and Department of Pharmacology (J.-S.H.), Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France; Université de Reims Champagne-Ardenne and Department of Anesthesiology and Critical Care Medicine, Robert Debré Hospital, Reims, France (A.C.); Wuhan University, Wuhan, The People’s Republic of China (C.J.); UMR INSERM 902 Université Evry Val d’Essone, Evry, France (S.B.); and Université Paris-Descartes, Paris, France (S.B.).
刊名: Anesthesiology, 2015, Vol.122 (2), pp.334-342
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/ALN.0000000000000526
原始语种摘要: BACKGROUND:: In the senescent heart, the positive inotropic response to β-adrenoceptor stimulation is reduced, partly by dysregulation of β1- and β3-adrenoceptors. The multidrug resistance protein 4 (MRP4) takes part in the control of intracellular cyclic adenosine monophosphate concentration by controlling its efflux but the role of MRP4 in the β-adrenergic dysfunction of the senescent heart remains unknown. METHODS:: The β-adrenergic responses to isoproterenol were investigated in vivo (stress echocardiography) and in vitro (isolated cardiomyocyte by Ionoptix with sarcomere shortening and calcium transient) in young (3 months old) and senescent (24 months old) rats pretreated or not with MK571, a specific MRP4 inhibitor. MRP4 was quantified in left ventricular homogenates by Western...
全文获取路径: Wolters Kluwer 
影响因子:5.163 (2012)

  • inotropic 变力的
  • adrenoceptor 肾上腺素能受体
  • sarcomere 肌节
  • shortening 缩短
  • stimulation 激励
  • isoproterenol 异丙基肾上腺素
  • efflux 
  • reduced 减缩的
  • adrenergic 肾上腺素性的
  • heart 心脏