Modification of the β-Adrenoceptor Stimulation Pathway in Zucker Obese and Obese Diabetic Rat Myocardium*
作者: Cheng JiangAude CarillionNa NaAudrey De JongSarah FeldmanJean-Marc LacorteDominique Bonnefont-RousselotBruno RiouJulien Amour
作者单位: 11Sorbonne Universités UPMC Univ Paris 06, UMR INSERM-UPMC 1166, IHU ICAN, Paris, France. 2Emergency Department, Zonghnan Hospital, Wuhan University, Wuhan, The People’s Republic of China. 3Department of Anesthesiology and Critical Care Medicine, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 4Department of Emergency Medicine and Surgery, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 5Department of Anesthesia and Critical Care B, Hôpital Saint-Eloi, CHU de Montpellier, Montpellier, France. 6Department of Endocrinologic and Oncologic Biochemistry, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 7Department of Metabolic Biochemistry, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 8Department of Biochemistry, Faculty of Pharmacy, Université Paris Descartes, Paris, France.
刊名: Critical Care Medicine, 2015, Vol.43 (7), pp.e241-e249
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/CCM.0000000000000999
原始语种摘要: OBJECTIVES:: Although metabolic syndrome is associated with increased sympathetic activity that chronically stimulates β-adrenoceptors, the β-adrenoceptor signaling pathway has been poorly studied in this situation. We studied the β-adrenoceptor signaling pathway in Zucker lean, obese, and obese diabetic rats. DESIGN:: Experimental, prospective study. SETTING:: University medical research laboratory. SUBJECTS:: Adult male Zucker lean (control), obese, and obese diabetic rats. INTERVENTIONS:: The effects of β-adrenoceptor stimulation were investigated in vitro in isolated left ventricular papillary muscles in control, obese, and obese diabetic rats. β1-, β2-, and β3-adrenoceptors and multidrug resistance-associated protein 4 were quantified by Western Blotting. Triglyceride, cholesterol,...
全文获取路径: Wolters Kluwer 
分享到:
来源刊物:
影响因子:6.124 (2012)

×
关键词翻译
关键词翻译
  • 浓聚物 减缩的
  • adrenoceptor 肾上腺素能受体
  • diabetic 糖尿病患者
  • inotropic 变力的
  • stimulation 激励
  • obese 肥胖的
  • protein 蛋白质
  • associated 相关的
  • hyperglycemia 高血糖
  • reduced 减缩的
  • concentrations 减缩的