Adult neurogenesis from reprogrammed astrocytes
作者: Brian GriffithsAnvee BhutaniCreed Stary
作者单位: 1Department of Anesthesiology, Pain &;Perioperative Medicine, Stanford University School of Medicine, Stanford, CA
刊名: Neural Regeneration Research, 2020, Vol.15 (6), pp.973-979
来源数据库: Wolters Kluwer Journal
DOI: 10.4103/1673-5374.270292
原始语种摘要: The details of adult neurogenesis, including environmental triggers, region specificity, and species homology remain an area of intense investigation. Slowing or halting age-related cognitive dysfunction, or restoring neurons lost to disease or injury represent just a fraction of potential therapeutic applications. New neurons can derive from stem cells, pluripotent neural progenitor cells, or non-neuronal glial cells, such as astrocytes. Astrocytes must be epigenetically “reprogrammed” to become neurons, which can occur both naturally in vivo, and via artificial exogenous treatments. While neural progenitor cells are localized to a few neurogenic zones in the adult brain, astrocytes populate almost every brain structure. In this review, we will summarize recent research into neurogenesis...
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影响因子:0.144 (2012)

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关键词翻译
关键词翻译
  • neurogenesis 神经发生
  • pluripotent 多能的
  • epigenetic 后成的
  • cells 麻风细胞
  • progenitor 祖先
  • neurogenic 神经元的
  • adult 成体
  • localized 修]定位[域
  • potential 
  • mitotic 有丝分裂的