Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia
作者: Bing-Chao DongMei-Xuan LiXiao-Yin WangXi ChengYu WangTing XiaoJukka JolkkonenChuan-Sheng ZhaoShan-Shan Zhao
作者单位: 1Department of Neurology, The First Hospital of China Medical University, Shenyang, Liaoning Province
2Key Laboratory of Immunodermatology, Ministry of Health, Ministry of Education, Shenyang, Liaoning Province
3Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio
刊名: Neural Regeneration Research, 2020, Vol.15 (6), pp.1079-1085
来源数据库: Wolters Kluwer Journal
DOI: 10.4103/1673-5374.270416
原始语种摘要: Stromal cell-derived factor-1 and its receptor CXCR4 are essential regulators of the neurogenesis that occurs in the adult hippocampal dentate gyrus. However, the effects of CXCR7, a new atypical receptor of stromal cell-derived factor-1, on hippocampal neurogenesis after a stroke remain largely unknown. Our study is the first to investigate the effect of a CXCR7-neutralizing antibody on neurogenesis in the dentate gyrus and the associated recovery of cognitive function of rats in the chronic stage of cerebral ischemia. The rats were randomly divided into sham, sham + anti-CXCR7, ischemia and ischemia + anti-CXCR7 groups. Endothelin-1 was injected in the ipsilateral motor cortex and striatum to induce focal cerebral ischemia. Sham group rats were injected with saline instead of...
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影响因子:0.144 (2012)

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关键词翻译
关键词翻译
  • dentate 锯齿状的
  • neurogenesis 神经发生
  • gyrus 脑回
  • neutralizing 中和
  • ischemia 局部贫血
  • antibody 抗体
  • cerebral 大脑的
  • ischemic 福尔克曼氏麻痹
  • cognitive 修]认知[识
  • quadrant 象限