Modeling the Impact of Retention Interventions on Mother-to-Child Transmission of HIV: Results From INSPIRE Studies in Malawi, Nigeria, and Zimbabwe
作者: Elizabeth McCarthyJessica JosephGeoff FosterAlexio-Zambezio MangwiroVictor MwapasaBolanle OyeledunSam PhiriNadia A. Sam-AguduShaffiq Essajee
作者单位: 1*Applied Analytics Team, Clinton Health Access Initiative, Lusaka, Zambia; †Applied Analytics Team, Clinton Health Access Initiative, Boston, MA; ‡Ministry of Health and Child Care, Mutare, Zimbabwe; §Family AIDS Caring Trust, Mutare, Zimbabwe; ‖Clinton Health Access Initiative, Harare, Zimbabwe; ¶Department of Public Health, College of Medicine, University of Malawi, Blantyre, Malawi; #Centre for Integrated Health Programs, Abuja, Nigeria; **Lighthouse Trust, Lilongwe, Malawi; ††Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC; ‡‡Department of Public Health, School of Public Health and Family Medicine, College of Medicine, University of Malawi, Lilongwe, Malawi; §§International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria; ‖‖Division of Epidemiology and Prevention, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD; and ¶¶World Health Organization, Geneva, Switzerland.
刊名: JAIDS Journal of Acquired Immune Deficiency Syndromes, 2017, Vol.75 Suppl 2 , pp.S233-S239
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/QAI.0000000000001364
原始语种摘要: BACKGROUND:: Six implementation research studies in Malawi, Nigeria, and Zimbabwe tested approaches for improving retention in care among women living with HIV. We simulated the impact of their interventions on the probability of HIV transmission during pregnancy and breastfeeding. METHODS:: A computer-based state-transition model was developed to estimate the impact of the retention interventions. Patient-level data from the 6 studies were aggregated and analyzed, and weighted averages of mother-to-child transmission (MTCT) of HIV probabilities were presented. The average MTCT probability of the more successful interventions was applied to national estimates to calculate potential infections averted if these interventions were taken to scale. RESULTS:: Among the total cohort of 5742...
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  • HIV Hydraulic Isolation Valve
  • Nigeria 尼日利亚
  • breastfeeding 母乳保育
  • retention 保留
  • infant 幼儿
  • pregnant 怀孕的
  • intervention 
  • AIDS Acoustic Intelligence Data System
  • statistically 统计地
  • estimate 估计