Ketamine increases the expression of GluR1 and GluR2 α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor subunits in human dopaminergic neurons differentiated from induced pluripotent stem cells
作者: Ginetta ColloLaura CavalleriCristiano ChiamuleraEmilio Merlo Pich
作者单位: 1Department of Molecular and Translational Medicine, University of Brescia, Brescia
2Department of Diagnostics and Public Health, University of Verona, Verona, Italy
3Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International AG, Zurich, Switzerland
刊名: NeuroReport, 2018
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/WNR.0000000000001185
原始语种摘要: The mechanisms underlying the prolonged antidepressant effects after a single exposure to ketamine are only partially understood. Converging findings indicate a critical role of structural neuroplasticity, recently also proposed for dopaminergic (DA) neurons known to be involved in a depression core symptom, anhedonia. We recently showed that ketamine induces dendritic outgrowth in human DA neurons differentiated in-vitro from induced pluripotent stem cells of healthy donors, a phenomenon blocked by the α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor antagonist NBQX. As changes in the expression of AMPA receptor subunits GluR1 and GluR2 were observed in neuroplasticity of rodent DA neurons, we aimed to explore this phenomenon in human DA neurons. Using specific antibodies...
全文获取路径: Wolters Kluwer 
影响因子:1.404 (2012)

  • isoxazole 异恶唑
  • propionate 丙酸盐
  • dopaminergic 多巴胺能的多巴胺能的
  • pluripotent 多能的
  • induced 感应的
  • hydroxy 羟基
  • receptor 接受体
  • expression 表示
  • human 人的
  • differentiated 区别