Ketamine effects on mammalian target of rapamycin signaling in the mouse limbic system depend on functional dopamine D3 receptors
作者: Cristiano ChiamuleraMarzia di ChioLaura CavalleriMarco VenniroLaura PadovaniGinetta Collo
作者单位: 1Department of Diagnostics & Public Health, University of Verona, Verona
2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
刊名: NeuroReport, 2018
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/WNR.0000000000001008
原始语种摘要: Ketamine is a noncompetitive glutamate N-methyl-D-aspartic acid receptor antagonist. When acutely administered to rodents, it produces a rapid antidepressant effect. There is evidence that N-methyl-D-aspartic acid receptor blockade enhances glutamatergic transmission preferentially engaging α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leading to mTOR (mammalian target of rapamycin) pathways activation, thus resulting into downstream neuroadaptive changes in limbic structures. Recent in-vitro data on primary neuronal cultures showed that ketamine activates mTOR also in dopaminergic neurons, and this activation depends on the presence of functional dopamine D3 receptors. The aim of this work was to study the in-vivo relevance of viable D3 receptors in mediating the effects...
全文获取路径: Wolters Kluwer 
影响因子:1.404 (2012)

  • limbic 边缘的
  • dopamine 多巴胺
  • rapamycin 雷帕霉素
  • ketamine 氯胺酮
  • substantia 
  • mammalian 哺乳动物
  • amygdala 扁桃
  • antidepressant 抗抑郁药
  • mouse 小鼠
  • nigra 黑质