Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells
作者: Jan A. GrawClaire MayeurIvy RosalesYumin LiuVenkata S. SabbisettiFrank E. RileyOsher RechesterRajeev MalhotraH. Shaw WarrenRobert B. ColvinJoseph V. BonventreDonald B. BlochWarren M. Zapol
作者单位: 11Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine; 2Department of Pathology; 4Department of Pediatrics, 5Cardiovascular Research Center and Cardiology Division; Department of Medicine, 6Division of Rheumatology, Allergy and Immunology; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Renal Division, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, MA
刊名: Circulation, 2016
来源数据库: Wolters Kluwer Journal
DOI: 10.1161/CIRCULATIONAHA.115.019955
原始语种摘要: BACKGROUND—: Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins haptoglobin and hemopexin, which bind extracellular hemoglobin and heme respectively. Transfusion of packed red blood cells (PRBCs) is a life-saving therapy for patients with hemorrhagic shock. Because erythrocytes undergo progressive deleterious morphological and biochemical changes during storage, transfusion of PRBCs that have been stored for prolonged intervals (SRBCs; stored for 35-40 days in humans or 14 days in mice) increases plasma levels of cell-free hemoglobin and heme. Therefore, in patients with hemorrhagic shock, perfusion-sensitive organs such as the kidneys are challenged not only by hypoperfusion, but also by the high...
全文获取路径: Wolters Kluwer  (合作)
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关键词翻译
关键词翻译
  • hemopexin 血液结合素
  • haptoglobin 亲血色蛋白
  • hemoglobin 血红蛋白
  • resuscitation 复苏
  • hemorrhagic 出血的
  • hypotension 低血压
  • receiving 接收
  • plasma 深绿玉髓
  • transfusion 输血
  • scavenger 食腐动物