Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression
作者: Dae Hae LeeBart KeymeulenRobert HilbrandsZhidong LingUrsule Van de VeldeDaniel Jacobs-Tulleneers-ThevissenGeert MaleuxBruno LapauwLaurent CrenierChristophe De BlockChantal MathieuDaniel PipeleersPieter Gillard
作者单位: 11 Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium. 2 University Hospital and Diabetes Research Center, Vrije Universiteit Brussel (VUB), Brussels, Belgium. 3 Department of Interventional Radiology, University Hospitals Leuven, KUL, Leuven, Belgium. 4 Department of Endocrinology, Gent University Hospital, Gent, Belgium. 5 Department of Endocrinology, Université Libre de Bruxelles-Hôpital Erasme, Bruxelles, Belgium. 6 Department of Diabetology, University Hospital Antwerp-UA, Antwerp, Belgium.
刊名: Transplantation, 2017, Vol.101 (9), pp.2218-2227
来源数据库: Wolters Kluwer Journal
DOI: 10.1097/TP.0000000000001543
原始语种摘要: BACKGROUND: Induction therapy with a T cell–depleting agent followed by mycophenolate mofetil and tacrolimus is presently the most frequently used immune suppression (IS) regimen in islet transplantation. This study assesses its safety and tolerability in nonuremic type 1 diabetic recipients. METHODS: Fifty-one patients (age, between 29 and 63 years) with high glycemic variability and problematic hypoglycemia received intraportal islet grafts under anti-thymocyte globulin-mycophenolate mofetil-tacrolimus protocol. They were followed up for over 48 months for function of the implant and adverse events. RESULTS: Severe hypoglycemia and diabetic ketoacidosis were absent in patients with functioning graft. Immune suppressive therapy was maintained for 48 months in 29 recipients with sustained...
全文获取路径: Wolters Kluwer 
影响因子:3.781 (2012)

  • hypoglycemia 低血糖
  • islet 
  • ketoacidosis 酮酸中毒
  • diabetic 糖尿病患者
  • events 定时
  • adverse 逆的
  • thymocyte 胸腺细胞
  • tacrolimus 血流谱
  • regimen 生活制度
  • protocol 日态